Explained: What is RLF-100 or Aviptadil, the 1970 drug being explored for Covid-19 treatment

News: An old drug formulation RLF-100 or Aviptadil is being probed to treat Covid-19 patients after initial studies have shown that the drug is able to halt SARS-CoV-2 virus replication in lungs.


  • RLF-100 or Aviptadil: It is an old proprietary drug formulation of synthetic human Vasoactive Intestinal Polypeptide(VIP).

Additional Facts:

  • Vasoactive Intestinal Polypeptide (VIP): It is released throughout the body but remains mostly concentrated in lungs.
  • Significance of VIP:
    • It is produced by immune cells and nerve endings and acts as a neurotransmitter.
    • It helps improve muscle activity and blood flow in the gastrointestinal tract.
    • It has anti-inflammatory and anti-cytokine activity properties that can help in alleviating respiratory distress in COVID19 patients.