Why US has cleared dengue vaccine with conditions,where India stands

  1. Recently,Sanofi Pasteur’s dengvaxia vaccine has been approved by the US Food & Drug Administration(FDA).It is the first dengue vaccine to get the regulatory nod in the US.But US FDA has said that it can be used only by those who have a previous history of the disease particularly in dengue-endemic areas
  2. Dengvaxia is a live,attenuated dengue virus.An attenuated virus is a virus that retains its properties of triggering an immune response in the body but its ability to lead to a disease is compromised.
  3. This vaccine has to be administered in people of ages 9 to 16 who have laboratory-confirmed previous dengue infection and who live in endemic areas.
  4. Dengvaxia is the first dengue vaccine to be licensed.Mexico had been the first country to clear it in 2015.Subsequently it has been cleared in some 20 countries.
  5. However,Dengvaxia had also ran into trouble two years ago when the Philippines had to suspend a school vaccination programme following several casualties.
  6. Further,India in 2017 had said that Sanofi will be allowed to be marketed in India after it had undergone phase III clinical trials that establish safety and efficacy of a drug on Indian subjects.
  7. According to the Centers for Disease Control and Prevention, an estimated 400 million dengue virus infections occur around the world.India is also among the dengue-endemic countries.
  8. Dengue is spread through the bite of an infected female Aedes Aegypti mosquito.The mosquito becomes infected when it feeds on the blood of a person infected with the virus.After about one week,the mosquito can then transmit the virus while biting a healthy person.

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